Repository logo
 
Publication

Identification of 'super-responders' to cardiac resynchronization therapy: the importance of symptom duration and left ventricular geometry

2009Journal article Open access
Simple item page
dc.contributor.authorAntónio, N
dc.contributor.authorTeixeira, R
dc.contributor.authorCoelho, L
dc.contributor.authorLourenço, C
dc.contributor.authorMonteiro, P
dc.contributor.authorVentura, M
dc.contributor.authorCristovão, J
dc.contributor.authorElvas, L
dc.contributor.authorGonçalves, L
dc.contributor.authorProvidência, LA
dc.date.accessioned2010-12-21T14:35:04Z
dc.date.available2010-12-21T14:35:04Z
dc.date.issued2009
dc.description.abstractAIMS: Some patients show such an important clinical improvement and reverse remodelling after cardiac resynchronization therapy (CRT) that anatomy and function approach normal. These patients have been called 'super-responders'. The aim of our study was to identify predictors of becoming a super-responder after CRT. METHODS AND RESULTS: Eighty-seven consecutive patients who underwent CRT were prospectively studied. Before CRT and 6 months after, clinical and echocardiographic evaluation was performed. Patients with a decrease in New York Heart Association functional class >or=1, a two-fold or more increase of left ventricular ejection fraction (LVEF) or a final LVEF >45%, and a decrease in LV end-systolic volume >15% were classified as super-responders. There were 12% super-responders. At baseline, there were no significant differences between super-responders and the other patients, except for the fact that super-responders had significantly smaller mitral regurgitation and LV end-diastolic diameter (LVEDD) and a shorter duration of heart failure symptoms. Mitral regurgitation jet area, LVEDD, and duration of heart failure symptoms were correlated with this super-response. Moreover, an evolution of symptoms for <12 months was an independent predictor of super-response to CRT. CONCLUSION: Patients in earlier phases of the cardiomyopathy, with a less altered ventricular geometry, seem to have a greater probability of becoming super-responders.por
dc.identifier.citationEuropace. 2009 Mar;11(3):343-9.por
dc.identifier.urihttp://hdl.handle.net/10400.4/913
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectMiocardiopatia Dilatadapor
dc.subjectDisfunção Ventricular Esquerdapor
dc.titleIdentification of 'super-responders' to cardiac resynchronization therapy: the importance of symptom duration and left ventricular geometrypor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Identification of 'super-responders' to cardiac resynchronization therapy.pdf
Size:
174.44 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CAR - Artigos