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Stroke after MitraClip: Systematic Review and Meta-Analysis

2019-12-10Journal article Open access
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dc.contributor.authorBarros da Silva, P
dc.contributor.authorSousa, JP
dc.contributor.authorOliveiros, B
dc.contributor.authorDonato, H
dc.contributor.authorCosta, M
dc.contributor.authorGonçalves, L
dc.contributor.authorTeixeira, R
dc.date.accessioned2019-12-27T13:22:27Z
dc.date.available2019-12-27T13:22:27Z
dc.date.issued2019-12-10
dc.description.abstractAIMS: To assess stroke rate after transcatheter mitral valve repair (TMVR) with MitraClip, comparing it with surgical mitral valve repair (SMVR) and optimal medical treatment (OMT). METHODS AND RESULTS: We systematically searched PubMed, Embase and Cochrane Controlled Register of Trials, in December 2018, for studies comparing TMVR with SMVR and/or OMT for the treatment of severe mitral regurgitation. Random-effects and cumulative meta-analysis was performed. Ten studies were included: seven of TMVR versus SMVR and three of TMVR versus OMT, providing a total of 1881 patients and 61 pooled strokes (16 in TMVR versus SMVR and 45 in TMVR versus OMT). There was no difference in stroke incidence between TMVR and SMVR (pooled OR 0.49 [0.17, 1.42], P=0.19). Cumulative meta-analysis showed a significantly lower stroke rate in TMVR, compared to SMVR (OR 0.4 [0.24, 0.67], P< 0.01). For TMVR versus OMT, no difference in stroke rate was identified (pooled OR 1.09 [0.60, 1.97], P=0.79). Post-procedure de novo atrial fibrillation was more frequent in SMVR when compared with TMVR. CONCLUSIONS: Although with a low number of pooled events, there was a trend for a lower post-procedure stroke in TMVR when compared with SMVR and a similar one between TMVR and OMT alone.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuroIntervention. 2019 Dec 10. pii: EIJ-D-19-00602.pt_PT
dc.identifier.doi10.4244/EIJ-D-19-00602pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/2269
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAcidente Vascular Cerebralpt_PT
dc.subjectInsuficiência da Válvula Mitralpt_PT
dc.subjectProcedimentos Cirúrgicos Minimamente Invasivospt_PT
dc.titleStroke after MitraClip: Systematic Review and Meta-Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiologypt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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