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Lifelong training improves anti-inflammatory environment and maintains the number of regulatory T cells in masters athletes

2017-06Journal article Open access
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dc.contributor.authorMinuzzi, LG
dc.contributor.authorRama, L
dc.contributor.authorBishop, NC
dc.contributor.authorRosado, F
dc.contributor.authorMartinho, A
dc.contributor.authorPaiva, A
dc.contributor.authorTeixeira, AM
dc.date.accessioned2018-12-28T16:23:09Z
dc.date.available2018-12-28T16:23:09Z
dc.date.issued2017-06
dc.description.abstractPURPOSE: The purpose of this study was to quantify and characterize peripheral blood regulatory T cells (Tregs), as well as the IL-10 plasma concentration, in Masters athletes at rest and after an acute exhaustive exercise test. METHODS: Eighteen Masters athletes (self-reported training: 24.6 ± 1.83 years; 10.27 ± 0.24 months and 5.45 ± 0.42 h/week per each month trained) and an age-matched control group of ten subjects (that never took part in regular physical training) volunteered for this study. All subjects performed an incremental test to exhaustion on a cycle ergometer. Blood samples were obtained before (Pre), 10 min into recovery (Post), and 1 h after the test (1 h). RESULTS: Absolute numbers of Tregs were similar in both groups at rest. Acute exercise induced a significant increase in absolute numbers of Tregs at Post (0.049 ± 0.021 to 0.056 ± 0.024 × 109/L, P = 0.029 for Masters; 0.048 ± 0.017 to 0.058 ± 0.020 × 109/L, P = 0.037 for control) in both groups. Treg mRNA expression for FoxP3, IL-10, and TGF-β in sorted Tregs was similar throughout the trials in both groups. Masters athletes showed a higher percentage of subjects expressing the FoxP3 (100% for Masters vs. 78% for Controls, P = 0.038) and TGF-β (89% for Masters vs. 56% for Controls, P = 0.002) after exercise and a higher plasma IL-10 concentration (15.390 ± 7.032 for Masters vs. 2.411 ± 1.117 for control P = 0.001, ES = 2.57) at all timepoints. KLRG1 expression in Tregs was unchanged. CONCLUSION: Our findings showed that Masters athletes have elevated anti-inflammatory markers and maintain the number of Tregs, and may be an adaptive response to lifelong training.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Appl Physiol. 2017 Jun;117(6):1131-1140.pt_PT
dc.identifier.doi10.1007/s00421-017-3600-6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/2193
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectExercíciopt_PT
dc.subjectInterleucina-10pt_PT
dc.subjectLinfócitos T Reguladorespt_PT
dc.titleLifelong training improves anti-inflammatory environment and maintains the number of regulatory T cells in masters athletespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1140pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1131-1140pt_PT
oaire.citation.volume117pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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