Repository logo
 
Publication

Hypertension induced by immunosuppressive drugs: a comparative analysis between sirolimus and cyclosporine

2009Journal article Open access
Simple item page
dc.contributor.authorReis, F
dc.contributor.authorParada, B
dc.contributor.authorTeixeira de Lemos, E
dc.contributor.authorGarrido, P
dc.contributor.authorDias, A
dc.contributor.authorPiloto, N
dc.contributor.authorBaptista, S
dc.contributor.authorSereno, J
dc.contributor.authorEufrásio, P
dc.contributor.authorCosta, E
dc.contributor.authorRocha-Pereira, P
dc.contributor.authorSantos-Silva, A
dc.contributor.authorFigueiredo, A
dc.contributor.authorMota, A
dc.contributor.authorTeixeira, F
dc.date.accessioned2009-06-09T15:18:19Z
dc.date.available2009-06-09T15:18:19Z
dc.date.issued2009
dc.description.abstractThe purpose of this study was to compare the effects of sirolimus (SRL) vs cyclosporine (CsA) concerning the cardiovascular mechanisms hypothetically contributing to hypertension development. Three rat groups were studied: control (vehicle), CsA (5 mg/kg/d), and SRL (1 mg/kg/d). The following parameters were evaluated after 7 weeks of treatment: blood pressured (BP) and heart rate (HR; tail cuff), lipid profile, hematology, plasma and platelet 5-HT and catecholamines (HPLC-ECD), and oxidative equilibrium (serum malondialdehyde [MDA] and total antioxidant status [TAS]). Systolic (SBP) and diastolic blood pressure (DBP) values were higher (P < .001) in both the CsA (146.2 +/- 4.5 and 124.9 +/- 4.5 mm Hg) and SRL (148.9 +/- 4.8 and 126.4 +/- 6.0 mm Hg) groups vs the controls (115.9 +/- 3.3 and 99.1 +/- 2.0 mm Hg). However, HR values were elevated in CsA but not SRL animals. The dyslipidemic pattern of CsA was even more enhanced in the SRL group, with significantly higher low-density lipoprotein cholesterol (LDL-c) and triglyceride (TG) levels vs CsA (P < .05); red blood cells, hematocrit, hemoglobin concentration, mean platelet volume, and platelet distribution width were significantly (P < .05) higher in the SRL vs CsA group. The pro-oxidative profile (increased MDA/TAS) in the CsA group was not reproduced in the SRL cohort. While plasma and platelet 5-HT were elevated in SRL rats, catecholamine content was higher in CsA animals. In conclusion, this study demonstrated that CsA and SRL produce identical hypertensive effects. However, while CsA promotes oxidative stress and sympathetic activation, SRL mainly interferes with lipid profile and hematological parameters. Thus, the hypertensive effects of CsA, a calcineurin inhibitor, and of SRL, an mTOR inhibitor, are associated with impairment of distinct cardiovascular pathwaysen
dc.identifier.citationTransplant Proc. 2009 Apr;41(3):868-73.en
dc.identifier.urihttp://hdl.handle.net/10400.4/526
dc.language.isoengen
dc.publisherElsevieren
dc.rights.uriopenAccessen
dc.subjectHipertensãoen
dc.subjectCiclosporinaen
dc.subjectSirolimusen
dc.titleHypertension induced by immunosuppressive drugs: a comparative analysis between sirolimus and cyclosporineen
dc.typejournal article
dspace.entity.typePublication
rcaap.typearticleen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Hypertension induced by immunosuppressive drugs.pdf
Size:
580.21 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.8 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

NEF - Artigos
UR - Artigos