Publication
Cardiac allograft systolic function. Is the aetiology (ischaemic or idiopathic) a determinant of ventricular function in the heart transplant patient?
| dc.contributor.author | Antunes, MJ | |
| dc.contributor.author | Biernet, M | |
| dc.contributor.author | Sola, E | |
| dc.contributor.author | Oliveira, L | |
| dc.contributor.author | Prieto, D | |
| dc.contributor.author | Franco, F | |
| dc.contributor.author | Providência, LA | |
| dc.date.accessioned | 2009-05-20T14:41:25Z | |
| dc.date.available | 2009-05-20T14:41:25Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | The natural history of the LV systolic function (LV-SF) and functional capacity of survivors of heart transplantation (Htx) has not been defined. Some investigators suggest that SF may be different in recipients with different pre-transplant aetiologies: ischaemic or dilated, idiopathic disease. Routine transthoracic echocardiograms (TTE) were performed during a 1-year follow-up in 48 Htx recipients (total 864 examinations; mean 18/patient). Patients were divided into two groups based on pre-transplant diagnosis: ischaemic (CAD-CMP: n=13, age 54+/-1.7 years, 23% females) and idiopathic dilated cardiomyopathy (ID-CMP: n=35, age 51+/-2.3 years, 26% females). Patients with valvular and toxic aetiology were excluded. All patients underwent left ventriculography (VENT) 12-15 months after Htx. The majority of 1-year survivors of Htx maintained normal LV-SF: mean LVEF 65+/-4% by echocardiography and 68+/-3% by ventriculography, but in the ID-CMP group LVEF was significantly higher: 67+/-4% vs. 62+/-4% (TTE) and 77+/-4% vs. 60+/-4% (VENT), without significant differences in functional capacity (NYHA). 82.9% of ID-CMP patients had LVEF >65% vs. 39% in CAD-CMP. The incidence of acute cellular rejection, freedom from cardiac vasculopathy, renal failure, diabetes, hypertension and pre-transplant alloantibody level was similar. Our study shows a strong correlation between pre-transplant heart disease and the systolic function of the cardiac allograft at 1-year follow-up. | en |
| dc.identifier.citation | Interact Cardiovasc Thorac Surg. 2008 Aug;7(4):586-90 | en |
| dc.identifier.uri | http://hdl.handle.net/10400.4/505 | |
| dc.language.iso | eng | en |
| dc.rights.uri | openAccess | en |
| dc.subject | Insuficiência Cardíaca | en |
| dc.subject | Miocardiopatias | en |
| dc.subject | Transplantação de Coração | en |
| dc.subject | Sobrevivência de Enxerto | en |
| dc.title | Cardiac allograft systolic function. Is the aetiology (ischaemic or idiopathic) a determinant of ventricular function in the heart transplant patient? | en |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.type | article | en |