Publication
Diabetes as an outcome predictor after heart transplantation
| dc.contributor.author | Saraiva, J | |
| dc.contributor.author | Sola, E | |
| dc.contributor.author | Prieto, D | |
| dc.contributor.author | Antunes, MJ | |
| dc.date.accessioned | 2011-09-07T13:14:25Z | |
| dc.date.available | 2011-09-07T13:14:25Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | We aimed to compare post-transplantation morbidity and survival among heart transplant recipients with and without diabetes mellitus. A retrospective review of 141 adult patients submitted to heart transplantation from November 2003 to June 2009 (with a minimum follow-up of one year) was undertaken. The patients were divided into two groups: those with (29%) and those without (71%) pre-transplantation diabetes. Those with diabetes were older (57.6±6.1 vs. 52.3±11.1 years; P=0.020) and had lower creatinine clearance (53.6±15.1 vs. 63.7±22.1; P=0.029). Nine patients died in hospital (6.4%; P=non-significant). No significant differences in lipid profiles (diabetes vs. no diabetes) existed before transplantation or at one year afterwards. Patients with diabetes showed a significant deterioration in their one-year lipid profile (158±43 vs.192±38 mg/dL; P=0.001), although one-year fasting diabetic was lower than before (178±80 vs. 138±45 mg/dL; P=0.016). During the first year, 17 (17%) patients previously free of diabetes developed new-onset diabetes. No significant differences were seen in rejection at one year (14% vs. 20%), infection (31% vs. 33%), new-onset renal dysfunction (8% vs. 14%) or mortality (17% vs. 7%). One-year survival was not significantly different (83% vs. 94%), but there was a significant decrease in the survival of individuals with diabetes at three years (73% vs. 91%; P=0.020). No significant difference was found in one-year survival or in terms of higher morbidity in the heart transplant patients with diabetes, but a longer follow-up showed a significant decrease in survival. Nonetheless, the patients with diabetes benefited significantly from transplantation and should not be excluded from it. | por |
| dc.identifier.citation | Interact Cardiovasc Thorac Surg. 2011 Aug 11. [Epub ahead of print] | por |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1064 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.subject | Diabetes Mellitus | por |
| dc.subject | Transplantação de Coração | por |
| dc.title | Diabetes as an outcome predictor after heart transplantation | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |