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Hidden musculoskeletal involvement in inflammatory bowel disease: a multicenter ultrasound study

2016-02-16Journal article Open access
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dc.contributor.authorRovisco, J
dc.contributor.authorDuarte, C
dc.contributor.authorBatticcioto, A
dc.contributor.authorSarzi-Puttini, P
dc.contributor.authorDragresshi, A
dc.contributor.authorPortela, F
dc.contributor.authorGutierrez, M
dc.date.accessioned2016-11-25T14:37:08Z
dc.date.available2016-11-25T14:37:08Z
dc.date.issued2016-02-16
dc.description.abstractBACKGROUND: Inflammatory bowel diseases are associated with a variety of extra-intestinal manifestations. The most frequent of these is joint involvement, which affects 16-33 % of IBD patients. Our aim was to evaluate the ultrasound prevalence of sub-clinical joint and entheseal involvement in patients with IBD without musculoskeletal symptoms, and to correlate the US findings with clinical and laboratory variables. METHODS: We recorded the clinical and laboratory data of 76 patients with IBD, 20 patients with spondyloarthritis (SpA) and 45 healthy controls at three rheumatology centers. All of the IBD patients and healthy controls were clinically examined by a rheumatologist in order to confirm the absence of musculoskeletal symptoms, and all of the subjects underwent grey-scale (GS) and power Doppler (PD) US examinations of the second and third metacarpophalangeal joints, knees and lower limbs in order to detect joint or entheseal abnormalities. RESULTS: A total of 1410 entheseal sites and 1410 joints were evaluated by US. Of the 76 patients with IBD, 64 (84.1 %) had at least one GS entheseal abnormality, and 11 (13.9 %) had more than one PD-positive entheseal site; 32 (42.1 %) showed sub-clinical joint involvement. There was a significant difference between the IBD patients and healthy controls in terms of global entheseal, PD-positive entheseal, and joint involvement (p < 0.0001), but no difference between the IBD and SpA patients. Anti-neutrophil cytoplasmic antibodies predicted entheseal involvement in patients with IBD (OR 6.031; p = 0.015). CONCLUSIONS: The prevalence of sub-clinical joint and entheseal involvement was higher in IBD patients than healthy controls, but there was no difference between the IBD and SpA patients.pt_PT
dc.identifier.citationBMC Musculoskelet Disord. 2016 Feb 16;17:84.pt_PT
dc.identifier.doi10.1186/s12891-016-0932-zpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/1976
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAdultpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectInflammatory Bowel Diseasespt_PT
dc.subjectJoint Diseasespt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMusculoskeletal Painpt_PT
dc.subjectSingle-Blind Methodpt_PT
dc.subjectYoung Adultpt_PT
dc.subjectDoença Inflamatória Intestinalpt_PT
dc.subjectDoenças Musculoesqueléticaspt_PT
dc.titleHidden musculoskeletal involvement in inflammatory bowel disease: a multicenter ultrasound studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage84pt_PT
oaire.citation.volume17pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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