Publication
Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allergy
| dc.contributor.author | Pontén, A | |
| dc.contributor.author | Aalto-Korte, K | |
| dc.contributor.author | Agner, T | |
| dc.contributor.author | Andersen, KE | |
| dc.contributor.author | Gimenez-Arnau, AM | |
| dc.contributor.author | Gonçalo, Margarida | |
| dc.contributor.author | Goossens, A | |
| dc.contributor.author | Johansen, JD | |
| dc.contributor.author | Le Coz, CJ | |
| dc.contributor.author | Maibach, HI | |
| dc.contributor.author | Rustemeyer, T | |
| dc.contributor.author | White, IR | |
| dc.contributor.author | Bruze, M | |
| dc.date.accessioned | 2014-04-03T09:43:02Z | |
| dc.date.available | 2014-04-03T09:43:02Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | BACKGROUND: The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. OBJECTIVES: To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. MATERIALS AND METHODS: In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2)) and 1.0% (wt/vol) (0.30 mg/cm(2)) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. RESULTS: Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. CONCLUSION: On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series. | por |
| dc.identifier.citation | Contact Dermatitis. 2013;68(1):50-3. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.4/1674 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Wiley | por |
| dc.subject | Formaldeído | por |
| dc.subject | Testes Cutâneos | por |
| dc.subject | Testes Patch | por |
| dc.subject | Dermatite de Contacto Alérgica | por |
| dc.subject | Alergénios | por |
| dc.title | Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allergy | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |