Browsing by Author "Trindade, L"
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- Cerebral Venous Thrombosis as Rare Presentation of Herpes Simplex Virus EncephalitisPublication . Leite, J; Ribeiro, A; Gonçalves, D; Sargento-Freitas, J; Trindade, L; Duque, VHerpes simplex virus 1 is a prevalent neurotropic pathogen that infects and establishes latency in peripheral sensory neurons. It can migrate into the central nervous system and cause encephalitis. The association between herpes simplex virus encephalitis and cerebral venous thrombosis is rare, with a very limited number of case reports described in the literature, despite the recognized thrombogenic effects of the virus. A 44-year-old man was brought to the emergency department with generalized tonic-clonic seizures requiring sedation and ventilation to control it. Initial brain computed tomography revealed cortical and subcortical edema on the left frontal lobe, and a subsequent contrast-enhanced exam showed absence of venous flow over the anterior half of the superior sagittal sinus. Cerebrospinal fluid polymerase chain reaction was positive for herpes simplex virus type 1, and the patient was started on acyclovir and anticoagulation, with clinical improvement. Acyclovir administration was maintained for 14 days and oral anticoagulation for one year, with no recurrence of thrombotic events or other complications. A well-timed treatment has a validated prognostic impact on herpes simplex encephalitis, making early recognition of its clinical aspects of main importance.
- Detection of the protease codon 35 amino acid insertion in sequences from treatment-naïve HIV-1 subtype C infected individuals in the Central Region of PortugalPublication . Pereira-Vaz, J; Duque, V; Trindade, L; Saraiva da Cunha, JG; Meliço-Silvestre, ABACKGROUND: Amino acids insertions in the protease (PR) coding region have been reported in protease inhibitors (PIs) treatment-naïve and experienced HIV-1 infected individuals ranging from 0.1% to 4.55% and have been rarely found in non-B HIV-1 subtype strains. OBJECTIVES: To investigate the presence of amino acid insertions in the PR coding region in sequences from treatment-naïve HIV-1 infected individuals in the Central Region of Portugal. STUDY DESIGN: Sequences of the pol gene from 260 treatment-naïve HIV-1 infected individuals between 2000 and 2008 were analyzed and phylogenetic analysis was performed. RESULTS: A threonine insertion (E35E_T) was detected in 2.69% (n=7) of the sequences analyzed and all the sequences that possessed this insertion were identified as subtype C. All the seven inserted sequences clustered in the same lineage of the phylogenetic tree. Heterosexual and intravenous drug use were found to be the routes of infection. No major mutations in the PR coding region associated with resistance to PIs were detected. CONCLUSIONS: It was found the highest prevalence of PR codon 35 insertion among treatment-naïve HIV-1 infected individuals ever reported in the western countries. Epidemiological data and Phylogenetic analysis indicated the possibility of transmission of this insertion. The results suggested that these inserted strains have normal susceptibility to PIs containing regimens. This study demonstrated the spreading epidemic of PR codon 35 inserted strains from subtype C in the Central Region of Portugal, during the past eight years.
- Leptospirose: casuística do Serviço de Infecciologia do Centro Hospitalar de Coimbra 1990-2007Publication . Speidel, A; Faísca, R; Fernandes, C; Vieira, AA; Barros, MS; Valente, C; Trindade, L; Faria, MJ; Almeida, H; Correia, L
- Prevalência do Anticorpo contra o VHA numa população na Região Centro de PortugalPublication . Speidel, A; Malaba, N; Marques, R; Alves, J; Veríssimo, R; Valente, C; Trindade, L; Correia, L
- Primo-infecção pelo vírus Epstein-Barr: forma menos vulgar de apresentaçãoPublication . Valente, C; Faria, MJ; Trindade, L; Barros, MS; Vieira, AA