Browsing by Author "Ribeiro, C"
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- Characterisation of disease and exacerbations in patients hospitalized with asthma attacks without previous attendance of a specialized departmentPublication . Calado, G; Loureiro, G; Tavares, B; Pereira, C; Ribeiro, C; Machado, D; Chieira, C
- Clinical respiratory allergy patterns in pairs of siblingsPublication . Calado, G; Loureiro, G; Tavares, B; Pereira, C; Ribeiro, C; Machado, D; Chieira, C
- Dermatite herpetiforme como manifestação inicial de doenças celíaca durante a gravidez: caso clínicoPublication . Calado, G; Loureiro, G; Ribeiro, C; Machado, D; Tavares, B; Chieira, CA doença celíaca (DC) é uma enteropatia induzida pela gliadina dos cereais. A prevalência tem vindo a aumentar, designadamente os casos atípicos e em idade adulta, comparativamente à apresentação clássica da infância, com manifestações gastrintestinais e decorrentes da malabsorção. Apresentamos um caso clínico de DC que se manifestou em idade adulta e cuja forma de apresentação foi a dermatite herpetiforme, durante a gravidez. Após um correcto enquadramento clínico e instituição de dieta sem glúten, verificou-se estabilização clínica. No entanto, a doente apresenta esterilidade secundária. Discute -se a interacção entre a DC e a gravidez, já que não só a DC pode ter repercussões na gravidez, como o inverso também se verifica.
- A diabetes na quarta idade: a nossa realidadePublication . Paiva, I; Baptista, C; Ribeiro, C; Leitão, P; Carvalheiro, MAIM: To evaluate the impact of the aging of our population in the growing of diabetes prevalence, among patients treated inward at our department. MATERIAL AND METHODS: The clinical files of 242 diabetics older than eighty years, treated between 1999 and 2002 were studied retrospectively. Demographic (sex, age, year of first contact), clinical (causes of admission, co-morbidities, duration of diabetes, previous hypoglycaemic treatment, duration of hospitalisation and evolution) and biochemical (glycaemia, HbA1c, lipaemia and C-peptide) data were recorded. RESULTS: A progressive rising in the number of aged patients was found during this period (seven in 1999 to 55 in 2002), with a large proportion of women (73%). The more frequent causes of in-hospital treatment were hyperglycaemia (20.6%) and feet ulcers (septic or necrotic) (16.5%). In nearly 42% of the cohort an acute infection was found. Diabetes was unknown in 13% of cases and less than ten years of duration in 38%. In this cohort most of the patients (77%) were treated with oral hypoglycaemic drugs, mostly sulfonylureas. HbA1c mean value was 10.4 +/- 2.2%; C -peptide was measured in a subset of cases (n=79), suggesting deficient insulin secretion in 18% of them. The global mean duration of hospitalisation was eleven days. Nineteen patients (8%) died during the hospitalization. CONCLUSIONS: In this study, we concluded that diabetes in people older than 75 years, is being progressively more often diagnosed. The general metabolic control was bad (HbA1c mean value--10.4 +/- 2.2%), with a significant number of patients presenting a deficient C-peptide secretion, worsened by frequent coexisting infections. So, a strengthened clinical care, directed to a careful diagnosis and treatment, may effectively contribute to a better prognosis and quality of life of aged diabetic patients.
- Egg allergy and Hodgkin´s lymphoma: case reportPublication . Calado, G; Loureiro, G; Machado, D; Ribeiro, C; Tavares, B; Pereira, C; Chieira, C
- Hand contact eczema could blind twicePublication . Machado, D; Pereira, C; Loureiro, G; Tavares, B; Calado, G; Ribeiro, C; Chieira, C
- Hipofisite Auto-imune ou LinfocíticaPublication . Paiva, I; Gomes, L; Ribeiro, C; Carvalheiro, M; Ruas, AThis entity, due to the pituitary lymphoplasmacytic infiltrate, was described for the first time in 1962. The clinical suspicion relies on a rapidly progressing hypopituitarism, particularly with adrenal involvement, affecting women in the peripartum period or patients with previously recognized autoimmune disease. Diabetes insipidus is also often reported. A sellar mass is found in 80% of cases. The diagnosis is confirmed by histology, due to the absence of a specific serological test. The endocrine deficiencies are frequently definitive. Corticotherapy is usually effective in reducing neurological symptoms due to pituitary enlargement, and frequently allows to avoid surgery. The disease-related deaths were due to acute adrenal insufficiency or ineffectively treated hypopituitarism. We are reporting a clinical case of probable lymphocytic hypophysitis in the early post partum of a woman with depression and Graves disease. She has hyperprolactinemia and ACTH deficiency, without pituitary changes in the magnetic resonance imaging. She was treated and her depression and hyperthyroidism were relieved. Hyperprolactinemia recovered spontaneously but she still needs glucocorticoid substitution.
- Hodgkin's lymphoma and late onset egg allergy: is there a causal relationship?Publication . Calado, G; Machado, D; Ribeiro, C; Loureiro, G; Tavares, B; Pereira, C; Cunha, R; Chieira, C
- Identification of a novel deletion in SURF1 gene: Heterogeneity in Leigh syndrome with COX deficiencyPublication . Ribeiro, C; Macário, MC; Viegas, AT; Pratas, J; Santos, MJ; Simões, M; Mendes, C; Bacalhau, M; Garcia, P; Diogo, L; Grazina, MLeigh syndrome (LS) is a rare, progressive neurodegenerative mitochondrial disorder of infancy. It is a genetically heterogeneous disease. The mutations in SURF1 gene are the most frequently known cause. Here two cases of LS likely caused by SURF1 gene variants are reported: a 39-year-old male patient with a novel homozygous deletion (c.-11_13del), and a case of a 6-year-old boy with the same deletion and a nonsense mutation (c.868dupT), both in heterozygosity. Blue native PAGE showed absence of assembled complex IV. This is the first report of a variant that may abolish the SURF1 gene initiation codon in two LS patients.
- Levothyroxine treatment in chronic urticaria associated with thyroid autoimmunityPublication . Machado, D; Pereira, C; Tavares, B; Loureiro, G; Calado, G; Ribeiro, C; Chieira, C
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