Browsing by Author "Pedroso de Lima, JJ"
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- A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative studyPublication . Pedroso de Lima, J; Pedroso de Lima, JJ; Isidoro, I; Lapa, PA method based upon the application of mathematical techniques of deconvolution on the classical compartmental model for the quantitative study of liver function from hepatobiliary scintigraphy using 99mTc-mebrofenin data is proposed. The theory in which the method is based upon is presented and a comparison with a published methodology of obtaining the hepatic extraction after scintigraphic sudies has been performed using the results on 36 rats studies obtained with the two methods. A highly significant correlation between the two techniques was verified. The characteristics of the two methodologies, the proposed one based upon a theoretical approach and the other one on an empirical approximation are discussed. Comments are made on the interest and limitations of the presented technique that may be an useful tool for the evaluation of hepatic insufficiency.
- Results of a multicenter SPECT study with [123I]-Iodolisuride in extrapyramidal syndromes.Publication . Ribeiro, MJ; Januário, C; Prunier, C; Chossat, F; Santos, AC; Mauclaire, L; Bekhechi, D; Marchand, J; Catela, L; Cunha, L; Pedroso de Lima, JJ; Baulieu, JLThe main objective of the present multicenter study was to evaluate -Iodolisuride (-ILIS) as a radioligand for dopamine receptors in patients (pts) with extrapyramidal diseases when using g-cameras of different types. 45 pts (28M, 17F) were studied in 2 centers (23+22 pts) and were divided in 2 groups: group I (n=28 age=66.8±3.5 years): idiopathic Parkinson’s disease; group II (n=17, age=57.5±7.1 years): other extrapyramidal syndromes. -ILIS (1.7 to 2.8 MBq/kg) was injected after informed consent. Single photon emission computed tomography (SPECT) studies were performed with a single head -camera (-camera A, GE 400AC*, 24 studies 1 hr p.i.), a dual head -camera (-camera B, Helix Elscint*, 15 studies 1hr to 2.5hr p.i.), a triple head -camera (-camera C, Neurocam GE*, 12 studies 45min to 2hr p.i.) and a brain dedicated annular detector (-camera -camera D, Ceraspect DSI*, 17 studies 1 to 3.5hr p.i.). Patients showed no undesirable reactions. All SPECT images obtained with different -cameras contained sufficient information for clinical interpretation and were qualitatively interpreted according to the visualization of basal ganglia (or striata) alone (type 1), visualization of cerebral cortex alone (type 2) and visualization of both basal ganglia and cerebral cortex (type 3) on the transversal slices. Striatal/frontal cortex ratios (S/FC) were calculated from standardized geometrical regions of interest. In group I, 45/45 SPECT images were classified as type 1 or type 3. In group II, 18/23 SPECT were classified as type 2 or 3. With any -camera, S/FC values were significantly higher in group I than in group II: -camera A: S/FC=1.48±0.20 vs. 1.26±0.25 (p=0,036), -camera B: S/FC=2.32±0.27 vs. 1.75±0.70 (p=0.025), -camera C: S/FC=1.55±0.22 vs. 1.34±0.15 (p=0.033), -camera D: S/FC=3.07±1.30 vs. 2.11±0.66 (p=0.039). We conclude that -ILIS imaging with any -camera provides functional information on striatal dopaminergic synapses in patients with extrapyramidal degenerative disease and could be useful in the differential diagnosis between Parkinson’s disease and other extrapyramidal syndromes. However, clinical use of -ILIS will require normalization and standardization of imaging and data processing procedures.