Browsing by Author "Nobre, RS"
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- Gastrenterite eosinofílicaPublication . Nobre, RS; Pina-Cabral, JEA gastrenterite eosinofílica é uma doença rara, caracterizada pela presença de infiltrado inflamatório eosinofílico em, pelo menos, um segmento do aparelho digestivo. A apresentação clínica é heterogénea, dependendo da localização, extensão e profundidade do processo inflamatório na parede do tubo digestivo. Pode haver associação com alergias e eosinofilia periférica. Os achados imagiológicos e endoscópicos são variáveis e inespecíficos, contribuindo somente para apoiar o diagnóstico. O tratamento da gastrenterite eosinofílica assenta fundamentalmente na corticoterapia. O prognóstico é globalmente favorável, sem risco acrescido de neoplasia gastrintestinal. Eosinophilic gastroenteritis is a rare disorder, characterized by eosinophilic infiltration of any part of the gastrointestinal tract. Clinical presentation is heterogeneous, depending on the site, length and depth of inflammation in the intestinal wall. Allergies and peripheral eosinophilia may be present. Radiographic and endoscopic findings are variable, nonspecific and only contribute to support the diagnosis. Corticosteroids are the mainstay of therapy. Prognosis is good and there is no increased risk of gastrointestinal malignancy.
- Hepatotoxicidade por Nimesulide: a propósito de um caso clínicoPublication . Nobre, RS; Romãozinho, JM; Ferreira, M; Amaro, P; Pina-Cabral, JE; Leitão, MA case of a forty-four years old rural female admitted due to vaginal discharge and inguinal lymphadenopathies is presented. She took nimesulide and, after two days, started with constitutional symptoms. At hospital admission she presented with jaundice, conjunctival suffusion and pharyngeal injection. Blood tests revealed cytopenia, marked hepatic citolysis, cholestasis, renal failure and reactive C protein elevation. Complementary studies showed positive antinuclear autoantibodies, mild elevation of immunoglobulins M and E, and a thickened gallbladder wall. Lymphocyte transformation test was positive for nimesulide. There was a clinical and laboratorial improvement after cessation of the drug. The authors discuss the main diagnostic hypotheses enfatizing definition criteria for hepatotoxicity and also the difficulty in establishing this diagnosis.