Browsing by Author "Moura, AL"
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- A New Terminal Nonsense Mutation of the Cathepsin C Gene in a Patient With Atypical Papillon-Lefèvre SyndromePublication . Moura, AL; Regateiro, FS; Peres Resende, E; Coimbra Silva, H; Gonçalo, M; Todo-Bom, A; Faria, E
- Pru p 3 sublingual immunotherapy ultra-rush protocol is safe and clinically effectivePublication . Moura, AL; Pereira, C; Regateiro, FS; Azevedo, J; Todo Bom, A; Carrapatoso, IIntroduction. Sublingual immunotherapy (SLIT) with Pru p 3 can prevent severe allergic reactions to LTP-containing foods, but the standard initiation protocol is time-consuming. Objectives. Establish the safety of a novel ultra-rush initiation protocol for SLIT with Pru p 3. Methods. Prospective study comparing the side effects of the standard vs novel ultra-rush initiation protocols of SLIT with Pru p 3 in patients with anaphylaxis to LTP. Results. Fifteen patients were included (standard initiation, 5; ultra-rush initiation, 10), 80% females. All patients had oropharyngeal pruritus during initiation, 80% with spontaneous recovery, but no other gastro-intestinal, respiratory, cutaneous or systemic side effects occurred in any patient of both groups. Conclusion. The novel ultra-rush protocol halved the build-up time without increasing side effects.