Browsing by Author "Martins, MI"
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- Endometrioid adenocarcinoma arising in endometriosis foci six years after estrogen replacement therapy: a case reportPublication . Areia, AL; Sousa, V; Frutuoso, C; Martins, MI; Oliveira, CFWe present a case of a 53-year-old woman who developed an endometrioid adenocarcinoma six years after total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO), who was on estrogenic-only hormone replacement therapy (HRT).
- Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with alpha-naphthyl-isothiocyanate (ANIT)Publication . Palmeira, CM; Ferreira, FM; Rolo, AP; Oliveira, PJ; Santos, MS; Moreno, AJ; Cipriano, MA; Martins, MI; Seiça, RThis study was designed to evaluate the effects of long-term treatment with alpha-naphthyl-isothiocyanate (ANIT) on liver histology and at the mitochondrial bioenergetic level. Since, ANIT has been used as a cholestatic agent and it has been pointed out that an impairment of mitochondrial function is a cause of hepatocyte dysfunction leading to cholestatic liver injury, serum markers of liver injury were measured and liver sections were analyzed in ANIT-treated rats (i.p. 80 mg/kg/week x 16 weeks). Mitochondrial parameters such as transmembrane potential, respiration, calcium capacity, alterations in permeability transition susceptibility and ATPase activity were monitored. Histologically, the most important features were the marked ductular proliferation, proliferation of mast cells and the presence of iron deposits in ANIT-treated liver. Mitochondria isolated from ANIT-treated rats showed no alterations in state 4 respiration, respiratory control ratio and ADP/O ratio, while state 3 respiration was significantly decreased. No changes were observed on transmembrane potential, but the repolarization rate was decreased in treated rats. Consistently with these data, there was a significant decrease in the ATPase activity of treated mitochondria. Associated with these parameters, mitochondria from treated animals exhibited increased susceptibility to mitochondrial permeability transition pore opening (lower calcium capacity). Since, human cholestatic liver disease progress slowly overtime, these data provide further insight into the role of mitochondrial dysfunction in the process.
- Proliferação celular e ploidia em esfregaços do colo uterino: estudo evolutivoPublication . Costa, FJ; Martins, MJ; Bombas, MT; Santos, PP; Diniz, M; Agapito, P; Manarte, A; Rodrigues, V; Oliveira, CF; Martins, MI; Oliveira, HM
- Sentinel node in breast cancer: preliminary results obtained at Gynaecology Department of the University Hospital of CoimbraPublication . Oliveira, V; Cruz, I; Amaral, N; Lapa, P; Oliveira, S; Silva, T; Martins, MI; Pedroso de Lima, J; Oliveira, CF
- Tumores do Peritoneu: a propósito de dois casos de pseudomixoma peritonealPublication . Sofia, A; Donato, A; Espírito-Santo, V; Freitas, D; Martins, MI; Leitão, M; Romãozinho, JM; Domingos, J; Urbano, M; Gouveia-Monteiro, J
- Valor prognóstico das proteínas p53, C-erB-2 E Ki67 no carcinoma do ovárioPublication . Frutuoso, C; Silva, MR; Amaral, N; Martins, MI; Oliveira, CF; Oliveira, HMThe prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely to respond to treatment. In order to evaluate the prognostic value of C-erb-B2, p53 and Ki 67 expression and correlate these markers with classic prognostic factors, we studied paraffin-embedded tumor tissue from 81 patients with epithelial ovarian cancer and made a quantitative evaluation of C-erb-B2, p53 and Ki 67 expression by immunohistochemistry. The results were: age 5.4 +/- 15(22-88); 66% with normal physical activity; 48.2% with residual disease < 2 cm; initial stage--42% and advanced stage--58%. Age, performance status, residual disease and stage were correlated with 2 and 5 years survival. Positive immunostaining: p53--87%, C-erb B-2--51% and Ki67--100%. P53 and C-erb B-2 were associated with residual disease and stage; patients with no C-erbB-2 staining had a significantly better survival. A direct and significant correlation was found between p53 and Ki67 and between C-erb B-2 and p53. We conclude that these markers have a high expression in ovarian carcinoma and p53 and C-er B-2 correlate with stage and residual disease. Although C-erb B-2 was associated with better survival, it was not found to be an independent prognostic factor.