Browsing by Author "Firmino, H"
Now showing 1 - 5 of 5
Results Per Page
Sort Options
- Auto-conceito e ansiedade socialPublication . Vaz-Serra, A; Gonçalves, S; Firmino, H
- Estudo clínico, multicêntrico, aberto, comparativo, sobre eficácia e a segurança da sertalina vs clomipramina, no tratamento de doentes com depressão moderada a gravePublication . Vaz-Serra, A; Firmino, H; Albuquerque, A; Ferreira, L; Sousa, P; Vieira, CR; Figueira, ML
- Relação entre auto-conceito e expectativasPublication . Vaz-Serra, A; Antunes, R; Firmino, H
- The neuroinflammatory hypothesis of deliriumPublication . Cerejeira, J; Firmino, H; Vaz-Serra, A; Mukaetova-Ladinska, EBDelirium is a neuropsychiatric syndrome characterized by a sudden and global impairment in consciousness, attention and cognition. It is particularly frequent in elderly subjects with medical or surgical conditions and is associated with short- and long-term adverse outcomes. The pathophysiology of delirium remains poorly understood as it involves complex multi-factorial dynamic interactions between a diversity of risk factors. Several conditions associated with delirium are characterized by activation of the inflammatory cascade with acute release of inflammatory mediators into the bloodstream. There is compelling evidence that acute peripheral inflammatory stimulation induces activation of brain parenchymal cells, expression of proinflammatory cytokines and inflammatory mediators in the central nervous system. These neuroinflammatory changes induce neuronal and synaptic dysfunction and subsequent neurobehavioural and cognitive symptoms. Furthermore, ageing and neurodegenerative disorders exaggerate microglial responses following stimulation by systemic immune stimuli such as peripheral inflammation and/or infection. In this review we explore the neuroinflammatory hypothesis of delirium based on recent evidence derived from animal and human studies.
- The Portuguese version of Mini-Tinnitus Questionnaire: brief screening test for assessment of tinnitus-induced stress.Publication . Cerejeira, R; Cerejeira, J; Paiva, S; Gonçalves, P; Firmino, H; Quartilho, MJ; Vaz-Serra, A; Paiva, AHYPOTHESIS: The Portuguese version of Mini-Tinnitus Questionnaire (Mini-TQ) is as valid as the English version to assess tinnitus-associated distress in the Portuguese-speaking population. BACKGROUND: Tinnitus is a major symptom in ENT practice affecting subjects in all demographic groups. Our objective is to validate a Portuguese version of Mini-TQ (Mini-TQ-pv) to be used in clinical practice and research. METHODS: Mini-TQ-pv was administered to 51 patients with chronic tinnitus. Statistical analysis was done to determine the psychometric properties of the instrument. RESULTS: After double translation, face and content validity were confirmed by high internal consistency (Cronbach alpha = 0.861) and significant correlation between individual items and total score. The questionnaire was easy and quick to administer (2.57 min). CONCLUSION: We provide a suitable Mini-TQ-pv to be used in the assessment of Portuguese-speaking patients with tinnitus