Browsing by Author "Figueiredo, A"
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- Abcesso hepático piogénico: a propósito de um caso clínicoPublication . Germano, E; Silva, C; Figueiredo, A; Sá, A
- Adrenalectomia parcial laparoscópica – será que vale a pena o esforço?Publication . Carvalho, J; Nunes, P; Antunes, H; Parada, B; Tavares da Silva, E; Retroz, E; Carrilho, F; Figueiredo, A
- Adverse cutaneous reactions to epidermal growth factor receptor inhibitors: a study of 14 patientsPublication . Santiago, F; Gonçalo, Margarida; Reis, JP; Figueiredo, ABACKGROUND: Cetuximab and erlotinib, epidermal growth factor receptor inhibitors, often cause peculiar adverse cutaneous reactions. OBJECTIVES: Our aim was to evaluate adverse cutaneous reactions and their management in patients undergoing treatment with cetuximab and erlotinib. PATIENTS AND METHODS: Between March/2005 and September/2009, we observed 14 patients with a mean age of 59.6 years undergoing treatment with cetuximab (7) or erlotinib (7), due to lung(10) or colorectal cancer (4). We evaluated the interval between introduction of the drug and onset of symptoms, treatment response, and the clinical pattern of evolution of the cutaneous reaction retrospectively. RESULTS: Twelve patients presented papular-pustular eruption typically affecting the face, chest and back, which appeared in average 13.5 days after starting the drug treatment. The patients underwent oral treatment with minocycline or doxycycline and topical treatment with metronidazole, benzoyl peroxide and/or corticosteroids. All patients showed improvement of the lesions. Five patients presented periungual pyogenic granulomas, which were associated with paronychia in 4 cases, after an average of 8 weeks of treatment. There was improvement of the lesions with topical treatment (antibiotics, corticosteroids and antiseptics). Xerosis was observed in some patients. Other less frequent adverse side effects such as telangiectasia and angiomas, hair and eyelash alterations, and eruptive melanocytic nevi were also described. Treatment with epidermal growth factor receptor inhibitor was maintained in most patients. CONCLUSION: The increasing use of these targeted therapies requires knowledge of their adverse cutaneous side effects to ensure timely intervention in order to allow the continuation of the therapy.
- Allergic and irritant occupational contact dermatitis from AlstroemeriaPublication . Mascarenhas, R; Robalo-Cordeiro, M; Fernandes, B; Oliveira, HS; Gonçalo, Margarida; Figueiredo, A
- Allergic contact and systemic dermatitis to estradiolPublication . Gonçalo, Margarida; Oliveira, HS; Monteiro, C; Clerins, J; Figueiredo, A
- Allergic contact dermatitis from minoxidilPublication . Ruas, E; Gonçalo, Margarida; Figueiredo, A; Gonçalo, S
- Allergic contact dermatitis from photobonded acrylic gel nails: a review of four cases.Publication . Cravo, M; Cardoso, JC; Gonçalo, Margarida; Figueiredo, A
- Allergic contact dermatitis to decyl glucoside in Tinosorb MPublication . Andrade, P; Gonçalo, Margarida; Figueiredo, A
- Allergic contact dermatitis to rubber-containing bandages in patients with leg ulcersPublication . Cravo, M; Gonçalo, Margarida; Figueiredo, A
- Allergic contact dermatitis to shoes induced by dimethylfumarate: A new allergen imported from ChinaPublication . Santiago, F; Andrade, P; Gonçalo, Margarida; Mascarenhas, R; Figueiredo, ABACKGROUND: In the last two years several cases of severe contact dermatitis related to newly acquired sofas and armchairs originating from China have been published. The responsible allergen is dimethylfumarate (DMF), an extremely potent sensitizer and irritant found in sachets inside the furniture. Recently, cases of contact dermatitis related to shoes and riding helmets have also been described. METHODS: We evaluated two patients with allergic contact dermatitis related to shoes manufactured in China that were contaminated by dimethylfumarate found in sachets placed inside the shoeboxes. RESULTS: Patch tests with DMF extracted from the sachets inside the shoeboxes showed positive reactions. Postitive reactions were also obtained using small fragments of the shoes and tissue of the "MouldProof" sachet. The patients were instructed to avoid the suspected shoes and were treated with topical corticosteroids. CONCLUSIONS: Contact dermatitis induced by dimethylfumarate should be suspected in appropriate cases. It is important to remember that this allergen is not included in most series for patch testing.