Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.4/554
Título: Immune phenotype of chronic liver disease
Autor: Czaja, JA
Santos, R
Porto, A
Santrach, PJ
Moore, SB
Palavras-chave: Doenças do Fígado
Data: 1998
Editora: Springer
Citação: Dig Dis Sci. 1998 Sep;43(9):2149-55
Resumo: Immune disorders in chronic liver disease may reflect common host propensities or disease-specific factors. Our aim was to determine the principal bases for these expressions. Four hundred fifty-one patients with various chronic liver diseases were assessed prospectively for concurrent immune disorders. Individuals with immune diseases were more frequently women (73% vs 60%, P = 0.02) and they had HLA DR4 more often than counterparts with other HLA (46% vs 23%, P = 0.000008). The association between HLA DR4 and immune disease was apparent within individual liver diseases and within different categories of liver disease. Women with HLA DR4 had a higher frequency of immune disease than women without HLA DR4 (52% vs 22%, P < or = 0.000001), and they also had immune diseases more commonly than DR4-positive men (52% vs 31%, P = 0.03). DR4-positive men, however, had higher frequencies of immune disease than DR4-negative men, especially in the nonimmune types of liver disease (26% vs 4%, P = 0.002). We conclude that HLA DR4 and female gender constitute an immune phenotype that is an important basis for autoimmune expression in chronic liver disease.
URI: http://hdl.handle.net/10400.4/554
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