Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.4/390
Título: Deposition and passage of transthyretin through the blood-nerve barrier in recipients of familial amyloid polyneuropathy livers
Autor: Sousa, MM
Ferrão, J
Fernandes, R
Guimarães, A
Geraldes, B
Perdigoto, R
Tomé, L
Mota, O
Negrão, L
Furtado, AL
Saraiva, MJ
Palavras-chave: Polineuropatia Amiloidótica Familiar
Transplantação de Fígado
Data: 2004
Editora: Nature Publishing Group
Citação: Lab Invest. 2004 Jul;84(7):865-73
Resumo: Familial amyloid polyneuropathy (FAP) is characterized by deposition of mutated transthyretin (TTR) in the peripheral nervous system. Prior to amyloid fibrils, nonfibrillar TTR aggregates are deposited inducing oxidative stress with increased nitration (3-NT). As the major source of TTR is the liver, liver transplantation (LT) is used to halt FAP. Given the shortage of liver donors, domino LT (DLT) using FAP livers is performed. The correlation between TTR deposition in the skin and nerve was tested in biopsies from normal individuals, asymptomatic carriers (FAP 0) and FAP patients; in FAP 0, nonfibrillar TTR was observed both in the skin and nerve in the same individuals; in patients, amyloid was detected in both tissues. The occurrence of amyloidosis in recipients of FAP livers was evaluated 1-7 years after DLT: TTR deposition occurred in the skin 3 years after transplantation either as amyloid or aggregates; in one of the recipients, fibrillar TTR was present in the epineurium 6 years after DLT. Deposits were scarce and 3-NT immunostaining was irrelevant. Nerve biopsies from DLT recipients had no FAP-related neuropathy. Our findings suggest that TTR amyloid formation occurs faster than predicted and that TTR of liver origin can cross the blood-nerve barrier. Recipients of FAP livers should be under surveillance for TTR deposition and tissue damage
URI: http://hdl.handle.net/10400.4/390
Aparece nas colecções:UR - Artigos
Transpl - Artigos
NEU - Artigos
MED - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Lab Invest.pdf256,64 kBAdobe PDFVer/Abrir

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.