Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.4/2154
Registo completo
Campo DCValorIdioma
dc.contributor.authorNagia, L-
dc.contributor.authorLemos, J-
dc.contributor.authorAbusamra, K-
dc.contributor.authorCornblath, WT-
dc.contributor.authorEggenberger, ER-
dc.date.accessioned2018-07-02T17:11:09Z-
dc.date.available2018-07-02T17:11:09Z-
dc.date.issued2015-07-
dc.identifier.citationOphthalmology. 2015 Jul;122(7):1517-21.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.4/2154-
dc.description.abstractPURPOSE: To calculate the rate and timing of conversion from ocular myasthenia gravis to generalized myasthenia gravis. DESIGN: Retrospective multicenter analysis. SUBJECTS: Patients included in the study were diagnosed with ocular myasthenia gravis without the presence of generalized disease at onset. METHODS: We conducted a retrospective multicenter analysis. We reviewed charts of 158 patients who met diagnostic criteria for ocular myasthenia gravis. Patients were divided into 2 subgroups: an immunosuppressant treatment group and a nonimmunosuppressant treatment group. Timing of conversion to generalized disease and duration of follow-up also was evaluated. Additional data such as clinical symptoms at presentation, laboratory test results, and chest imaging results also were recorded. MAIN OUTCOME MEASURES: Conversion rates to generalized myasthenia at 2 years, effect of immunosuppression on conversion, and timing of conversion. RESULTS: The 158-patient cohort included 76 patients who received immunosuppressant therapy; the remaining 82 patients did not. The overall conversion rate to generalized disease was 20.9%. At 2 years, generalized myasthenia developed in 8 of 76 patients in the treated group and in 15 of 82 patients in the nonimmunotherapy group (odds ratio, 0.52; 95% confidence interval, 0.20-1.32). Median time for conversion to generalized disease was 20 months in the nonimmunosuppressant group and 24 months in the immunosuppressant group. Conversion occurred after 2 years of symptom onset in 30% of patients. CONCLUSIONS: Conversion rates from ocular to generalized myasthenia gravis may be lower than previously reported both in immunosuppressed and nonimmunosuppressed patients. A subset of patients may continue to convert to generalized disease beyond 2 years from onset of symptoms, and close monitoring should be continued.pt_PT
dc.language.isoengpt_PT
dc.rightsopenAccesspt_PT
dc.subjectMiastenia Gravispt_PT
dc.titlePrognosis of Ocular Myasthenia Gravis: Retrospective Multicenter Analysispt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage1517-21pt_PT
degois.publication.issue7pt_PT
degois.publication.lastPage1521pt_PT
dc.peerreviewedyespt_PT
degois.publication.volume122pt_PT
dc.identifier.doi10.1016/j.ophtha.2015.03.010pt_PT
Aparece nas colecções:NEU - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
AAO.pdf528,11 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.