Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.4/2023
Título: Smoking and antidepressants pharmacokinetics: a systematic review
Autor: Oliveira, P
Ribeiro, J
Donato, H
Madeira, N
Palavras-chave: Anti-Depressivos
Tabaco
Perturbações Depressivas
Farmacocinética
Data: 2017
Citação: Ann Gen Psychiatry. 2017 Mar 6;16:17.
Resumo: Despite an increasingly recognized relationship between depression and smoking, little is known about how smoking influences antidepressant response and treatment outcomes. The aim of this study was to systematically review the evidence of the impact of smoking on new-generation antidepressants with an emphasis on the pharmacokinetic perspective. METHODS: We present a systematic review of clinical trials comparing the serum levels of new-generation antidepressants in smokers and nonsmokers. Data were obtained from MEDLINE/PubMed, Embase, and other sources. Risk of bias was assessed for selection, performance, detection, attrition, and reporting of individual studies. RESULTS: Twenty-one studies met inclusion criteria; seven involved fluvoxamine, two evaluated fluoxetine, sertraline, venlafaxine, duloxetine or mirtazapine, and escitalopram, citalopram, trazodone and bupropion were the subject of a single study. No trials were found involving other common antidepressants such as paroxetine or agomelatine. Serum levels of fluvoxamine, duloxetine, mirtazapine and trazodone were significantly higher in nonsmokers compared with smokers. CONCLUSIONS: There is evidence showing a reduction in the concentration of serum levels of fluvoxamine, duloxetine, mirtazapine and trazodone in smoking patients as compared to nonsmokers. The evidence regarding other commonly used antidepressants is scarce. Nonetheless, smoking status should be considered when choosing an antidepressant treatment, given the risk of pharmacokinetic interactions.
Peer review: yes
URI: http://hdl.handle.net/10400.4/2023
DOI: 10.1186/s12991-017-0140-8
Aparece nas colecções:PSI - Artigos
SD - Artigos

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