Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.4/1980
Título: Oxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug Resistance Proteins: Targets of Human Amniotic Membrane in Hepatocellular Carcinoma
Autor: Mamede, AC
Guerra, S
Laranjo, M
Santos, K
Carvalho, MJ
Carvalheiro, T
Moura, P
Paiva, A
Abrantes, AM
Maia, CJ
Botelho, MF
Palavras-chave: Proteínas Associadas à Resistência a Múltiplos Medicamentos
Stress Oxidativo
Data: Out-2016
Citação: Pathol Oncol Res. 2016 Oct;22(4):689-97.
Resumo: The anticancer effects of human amniotic membrane (hAM) have been studied over the last decade. However, the action mechanisms responsible for these effects are not fully understood until now. Previously results reported by our team proved that hAM is able to induce cytotoxicity and cell death in hepatocellular carcinoma (HCC), a worldwide high incident and mortal cancer. Therefore, this experimental study aimed to investigate the cellular targets of hAM protein extracts (hAMPE) in HCC through in vitro studies. Our results showed that hAMPE is able to modify oxidative stress environment in all HCC cell lines, as well as its cell cycle. hAMPE differently targets deoxyribonucleic acid (DNA), P21, P53, β-catenin and multidrug resistance (MDR) proteins in HCC cell lines. In conclusion, hAMPE has several targets in HCC, being clear that the success of this treatment depends of a personalized therapy based on the biological and genetic characteristics of the tumor.
Peer review: yes
URI: http://hdl.handle.net/10400.4/1980
DOI: 10.1007/s12253-016-0053-x
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