Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.4/1941
Título: Tourette's syndrome and associated disorders: a systematic review
Outros títulos: Cruzamento de patologias na síndrome de Tourette: uma revisão sistemática
Autor: Ferreira, BR
Pio-Abreu, JL
Januário, C
Palavras-chave: Síndrome de Tourette
Transtornos de Tique
Data: Set-2014
Citação: Trends Psychiatry Psychother. 2014 Sep;36(3):123-33.
Resumo: To compile data on Tourette's syndrome (TS), tics and associated disorders. METHODS: A systematic review of the literature was conducted using the 5S levels of organization of healthcare research evidence (systems, summaries, synopses, syntheses, studies), based on the model described by Haynes. The search keywords were Tourette, tics and comorbidity, which were cross-referenced. Studies provided by publishers and articles being processed on July 31, 2013, were also included. RESULTS: Of all studies retrieved during the search, 64 were selected because they analyzed the epidemiology, clinical features and etiopathogenesis of TS and its comorbidities. TS is classified as a hyperkinetic movement disorder, and at least 90% of the patients have neuropsychiatric comorbidities, of which attention deficit hyperactivity and obsessive-compulsive disorders are the most common. The syndrome is clinically heterogeneous and has been associated with a dysfunction of cortico-striatal-thalamic-cortical circuits involving various neurotransmitters. Although its genetic etiology has been widely studied, other factors may be important to understand this syndrome and its associated disorders. CONCLUSIONS: TS is a neurodevelopmental disorder that results from the impact of stress factors on a vulnerable biological substrate during the critical periods of neurodevelopment. The study of TS and its comorbidities may contribute, at different levels, to the understanding of several neuropsychiatric disorders of clinical and therapeutic relevance.
Peer review: yes
URI: http://hdl.handle.net/10400.4/1941
DOI: 10.1590/2237-6089-2014-1003
Aparece nas colecções:DER - Artigos
PSI - Artigos
NEU - Artigos

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