Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.4/1048
Título: Obsessive Compulsive Disorder as a functional interhemispheric imbalance at the thalamic level
Autor: Gonçalves, OF
Carvalho, S
Leite, J
Pocinho, F
Relvas, J
Fregni, F
Palavras-chave: Perturbação Obsessivo-Compulsiva
Data: 2011
Editora: Elsevier
Citação: Med Hypotheses. 2011 Sep;77(3):445-7.
Resumo: Obsessive Compulsive Disorder (OCD) involves failures in two main inhibitory processes, namely cognitive (obsessions) and behavioral (compulsions). Recent research has supported two cortical-subcortical pathways on OCD pathogenesis: (a) the frontostriatal loop (dorsolateral-caudate-striatum-thalamus) responsible for impairments of behavioral inhibition; (b) the orbitofrontal loop (orbitofrontal, medial prefrontal and cingulate) responsible for impairments with cognitive inhibitory processes. These failures in both cognitive and motor inhibitory systems may mediate several neuropsychological deficits in these patients, namely memory, attention, planning and decision making. But are those deficits related to specific hemispheric effects, namely functional imbalance between hemispheres? In this article we hypothesize that: (1) OCD patients have an inter-hemispheric functional imbalance, probably due to inadequate filtering at the thalamic level; (2) the restoration of inter-hemispheric balance, will be correlative to symptomatic improvement.
Peer review: yes
URI: http://hdl.handle.net/10400.4/1048
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